Clinical evaluation of calcium antagonists as anti-hypertensive agents

Calcium antagonists as anti-atherosclerotic agents.

Are calcium ion antagonists effective anti-atherogenic agents?

Clinical pharmacology of calcium antagonists. Satellite symposium on calcium antagonists.

A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...

TRPV1 Antagonists as Analgesic Agents

The last decade (2001 2010), declared as the Decade of Pain Control and Research by the United States Congress, brought significantly advances in our understanding of pain biology. Unfortunately, this has not translated into additional effective treatments of chronic pain conditions. Chronic pain is a debilitating and complex clinical state usually associated with diabetic neuropathy, postherpe...

Calcium antagonists: effects on cardio-renal risk in hypertensive patients.

Calcium antagonists comprise 2 main subclasses, dihydropyridines and nondihydropyridines, and have been studied extensively in hypertensive patients. Early meta-analyses suggested that short-acting calcium antagonists were associated with higher mortality rates resulting from cardiovascular events and other etiologies. Recent meta-analyses failed to show any substantive difference between long ...